Tirzepatide titration schedule
The whole ladder, converted into the exact number of units to draw at every stage. Change the vial or the water and it recalculates.
The schedule
| Stage | Weekly dose | Draw | U-100 units | Vials used by end |
|---|---|---|---|---|
| Weeks 1–4 | 2.5 mg | 0.25 mL | 25 units | 0.3 |
| Weeks 5–8 | 5 mg | 0.5 mL | 50 units | 1.0 |
| Weeks 9–12 | 7.5 mg | 0.75 mL | 75 units | 2.0 |
| Weeks 13–16 | 10 mg | 1 mL | 100 units | 3.3 |
| Weeks 17–20 | 12.5 mg | 1.25 mL | 125 units | 5.0 |
| Weeks 21–24 | 15 mg | 1.5 mL | 150 units | 7.0 |
Based on a 30 mg vial with 3 mL of bacteriostatic water (10 mg/mL) on a U-100 syringe, stepping every 4 weeks. Change any of that and the units change, so run your own numbers in the calculator above.
How to read it
Tirzepatide has a licensed titration ladder, which makes it the most clearly defined schedule on this site: 2.5 mg weekly for four weeks, then 5 mg, then steps of 2.5 mg every four weeks up to a maximum of 15 mg. The 2.5 mg stage is a starting dose intended to build tolerance, not a maintenance dose.
The licensed product is a pre-filled pen at a fixed concentration. If you reconstitute a vial yourself you choose the concentration, so unit counts quoted for a pen will not match your own.
Calculators by compound
Common questions
- What is the standard tirzepatide titration schedule?
- 2.5 mg once weekly for four weeks, then 5 mg for four weeks, then increases of 2.5 mg every four weeks as tolerated, up to a maximum of 15 mg weekly.
- How many units is each step?
- It depends on your concentration. In a 30 mg vial with 3 mL of water, which is 10 mg/mL, the ladder runs 25, 50, 75, 100, 125 and 150 units. The last two exceed a 1 mL syringe, so use less water if you are going high.
- Can I skip the 2.5 mg stage?
- The starting dose exists to build tolerance to gastrointestinal side effects. Skipping it is the usual reason people find the drug intolerable and stop.